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Volume:1, Issue:1- Research Article

Effect of GlutaMax® FORTE, a Multicomponent Dietary Supplementation Containing Silibinin-Phosphatidylcholine Complex, in Cats with Liver Diseases

Elena Biasibetti, Tiziana Cocca, Maria Teresa Capucchio, Stefano Togni, Ambra Corti, Luca Giacomelli*, Leonardo Giraudo, Mauro Bigliati, and Marco Barbara


Background: Dietary supplementation with hepatoprotective and antioxidant products could represent a beneficial strategy to prevent and treat liver pathology in cats. We evaluated the efficacy of long-term treatment with GlutaMax® FORTE, a multi-component dietary supplement containing functional natural ingredients with recognized hepatoprotective properties including the silibinin-phosphatidylcholine complex (SPC), in cats with liver diseases.

Methods: 20 European domestic cats, 10 with hepatic lipidosis and 10 with cholangitis received Glutamax® FORTE for 180 consecutive days. Clinical assessment and blood and urine parameters were evaluated at T0 and after 7, 28, 60, 90 and 180 days.

Results: After 180 days, cats reported a significantly reduced activity of liver enzymes in serum (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transferase) and a significant decrease in total bilirubin, albumin, pre- and post- bile acids concentrations, with normalization of liver function parameters. Moreover, following the supplementation, appetite was restored in all cats and the frequent episodes of diarrhea and vomit reported at inclusion almost disappeared.

Discussion: Dietary supplementation with GlutaMax® FORTE, thanks to the hepatoprotective and antioxidant axion of multiple natural ingredients including SPC, might represent an effective strategy to improve the conditions of liver dysfunction, such as hepatic lipidosis and cholangitis, in cats.

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